TARGETING TREATMENT RESISTANCE: UNVEILING THE POTENTIAL OF RNA METHYLATION REGULATORS AND TG-101,209 IN PAN-CANCER NEOADJUVANT THERAPY

Targeting treatment resistance: unveiling the potential of RNA methylation regulators and TG-101,209 in pan-cancer neoadjuvant therapy

Abstract Background Tumor recurrence and mortality rates remain challenging in cancer patients despite comprehensive treatment.Neoadjuvant chemotherapy and immunotherapy aim to eliminate residual tumor cells, reducing the risk of recurrence.However, drug resistance during neoadjuvant therapy is a significant hurdle.Recent studies suggest a correlat

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Public Health Leadership in a VUCA World Environment: Lessons Learned during the Regional Emergency Rollout of SARS-CoV-2 Vaccinations in Heidelberg, Germany, during the COVID-19 Pandemic

The purpose of this work is to share methods used and lessons learned during a comprehensive inter-institutional pandemic disaster response in Heidelberg, Germany, conveying experiences of the regional SARS-CoV-2 vaccination rollout campaign for up to 1,000,000 vaccines in the year 2020.In this volatile, uncertain, complex, and ambiguous (VUCA) env

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Bipolar Disorder in Women with Polycystic Ovarian Syndrome (PCO)

This study was designed to determine the prevalence of bipolar disorder in women with polycystic ovarian syndrome (PCO).One case of caymus hundred and ten women with definite diagnosis of PCO and one hundred and ten age-matched infertile women due to other reasons except for PCO were enrolled in this case-control study.Ten ml fasting venous blood s

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